Aricept 23 mg/day may help improve mental function in patients with moderate to severe Alzheimer's Disease, even in those who have not had success with Aricept 10 mg/d.
A patient must have been on 10 mg Aricept for at least 3 months before starting the higher dose preparation.
Approximately 1/5 patients discontinued due to side effects. Side effects leading to discontinuation (usually in the first month of treatment) include nausea, vomiting, diarrhea, anorexia and dizziness.
Slowing of the heart, heart block, GI bleeding (approx 1/200) were the more serious adverse events.
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